The OSD is well designed and worth spending a bit of time getting to know. Along with the obvious controls found on all monitors you will be able to tweak your response rate, HDR settings and even set up four shortcut keys if you so desire. For those without a colourimeter there are eight preset colour modes to choose from, with three game profiles you can program and store as well as a general custom colour profile.
You have a choice of four SDR modes, Desktop, Movie HDR, Game HDR and Display HDR, with an option to turn it off which disables HDR altogether. Honestly, I am hard pressed to determine a difference between the modes and switching between them until you are satisfied with one. There is a Freesync toggle on the monitor which you need to enable before playing with adaptive sync in your driver, be it AMD or NVIDIA. Along with Freesync is a option to switch between three response times, Fast, Super Fast and Extreme, which come in handy if you intend to run at 144Hz or 165Hz. In testing it seems Fast is perfect if you are using a base 60Hz but Super Fast is the way to go with high refresh rates as I could see some hints of ghosting when set to Extreme. You can find the full list of OSD controls in the PDF manual.
This is a Freesync 2 display and not on the list of G-SYNC compatible monitors, however it functions perfectly well in tandem with my ASUS ROG STRIX GTX 1080 GAMING Advanced. As it is not officially supported, as you can see in the screenshot, it is inadvisable to attempt to enable the specific settings for this monitor in your driver. Doing so resulted in black screens while gaming, sometimes permanent until exiting the game and sometimes flickering in and out, depending on the game engine. Some have found success enabling this feature if they drop the refresh rate to 144Hz or lower but in my experience leaving this unchecked allows games to play with the monitor set to 165Hz.
It is also worth mentioning Game Enhance Mode, which allows you to display your what refresh rate is at the monitor itself which is helpful when you create several custom desktop resolutions, say one 144Hz and one at the overclocked 165Hz.